Well depends what type of Anime you watch .. but to be honest, in the 42 series/movies I've seen so far, I'd say about 90% of them marked my life in a way. Although, I tend to watch anime thats aimed at an older crowd .. a lot of them are 18+ for that matter. Stuff like Ghost in the Shell and Gantz are solely based on taking different angles on how to view our morals and our lives. If you can't get anything out of those ones .. you can't get much out of a lot of things in life.